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4. Know your medicines and treatments?

26 th Jul 4. Know your medicines and treatments?

You guessed it…atorvastatin!

 

Best known as the drug ‘Lipitor’ and first synthesized in 1985 by Pfizer’s Bruce Roth; atorvastatin lowers the LDL-C (“bad” cholesterol) and triglycerides in blood. It was all made possible by the Japanese biochemist Akira Endo, who isolated the first statin, ‘mevastatin’, from fermentation broths while at Sankyo, a Japanese pharmaceutical company. Endo was searching for inhibitors of the enzyme HMG-CoA reductase, a key to the biosynthesis of cholesterol, as it had been long envisioned by researchers and scientists that blocking the synthesis of cholesterol would result in lower cholesterol levels in plasma.

 

 

References:

NCBI article , CEN.org , Chemheritage , Lipitor

 

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